Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Improved Oral Bioavailability of Chlorpromazine: In Vitro and In Vivo Evaluation

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Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery.Chlorpromazine, an antipsychotic agent with poor aqueous solubility—with extensive first-pass metabolism—can be a suitable candidate for the development of SNEDDS.The current study was designed to develop triglyceride-based SNEDDS of truvisionhealthftp.com chlorpromazine to achieve improved solubility, stability, and oral bioavailability.

Materials and Methods: Fifteen SNEDDS formulations of each short, medium, and long chain, triglycerides were synthesized and characterized to achieve optimized formulation.The optimized formulation was characterized for several in vitro and in vivo parameters.Results: Particle size, zeta potential, and drug loading of the optimized SNEDDS (LCT14) were found to be 178 ± 16, −21.

4, and 85.5%, respectively.Long chain triglyceride (LCT14) showed a 1.

5-fold increased elimination half-life (p < 0.01), up to 6-fold increased pentair hose oral bioavailability, and 1.7-fold decreased plasma clearance rate (p < 0.

01) compared to a drug suspension.Conclusion: The findings suggest that SNEDDS based on long-chain triglycerides (LCT14) formulations seem to be a promising alternative for improving the oral bioavailability of chlorpromazine.